Head of Biology (Vice President)

Contenuto del lavoro

Job Duties

• Responsible for establishing the strategy for the development of antibody and antibody-drug candidate (ADC)
• Work closely with CSO on forming a strategic plan to develop next-generation candidates
• Identification of potential targets for antibody development
• The upstream process of antibody development includes antibody construct design/engineering, characterization, and production to evaluate the drugability of the antibody.
• The downstream process of antibody development includes cell line development, clone selection, and identification of top clones with high titer for antibody production to evaluate the developability of the antibody.
• Conduct mechanism of action studies to explore potential interactions of multiple targets
• Conduct an in vivo study to evaluate the antitumor efficacy of the antibody-drug conjugate (ADC) derived from the antibody developed

Position Responsibilities

• Supervise multiple functional teams and provide strategic guidance for the teams
• Ensure cross-functional collaborations within the department as well as with other departments
• Execute the projects efficiently and make sure the objectives are delivered in a timely fashion
• Serve as team lead for antibody and antibody-derived drug discovery, engineering, early antibody process development, and characterization of the activity for candidate drug selection.
• As team lead for CRO selection on antibody discovery that aligns with the organization’s goals and objectives.
• Support antibody manufacturing CDMO selection.
• Take responsibility for tech transfer of antibody upstream process development protocol for manufacturing.
• Support document preparation for IND application.

Degree & Experience Requirements

• Ph.D. with oncology and/or immunology-related science background with experience in antibody and antibody-derived drug discovery and development.
• Minimum of 10 years of industrial experience in antibody drug discovery experience